DIALIGN-T: An improved algorithm for segment-based multiple sequence alignment
By Amarendran R. Subramanian
DIALIGN-T is an improved algorithm for segment-based multiple protein alignments. DIALIGN-T is a complete reimplementation of the segment-base approach including several new improvements and heuristics that significantly enhance the quality of the output alignments compared to DIALIGN 2.2. This significant superiority has been observed on local as well on global alignment benchmarks. An outline of the improvements can be found here.
The next version of DIALIGN-T which will also include methods for multiple DNA alignments will be released soon.
Quality Results
We assessed the quality of DIALIGN-T on the benchmark databases IRMase V1.0 and BALIBASE 2.1. The IRMBase database has been created by implanting motives generated by ROSE into random sequences. Details of the construction of the IRMBase V1.0 and performance results of DIALIGN-T can be found here.
Further Information and Citation
A detailed description of the algorithm is available in
- Amarendran R. Subramanian, Jan Weyer-Menkhoff, Michael Kaufmann, Burkhard Morgenstern: DIALIGN-T: An improved algorithm for segment-based multiple sequence alignment Bioinformatics 2005, 6:66.
Online Submission
Submit your data to DIALIGN-T using the web interface.
Download
DIALIGN-T is freely available under the GNU Lesser General Public License (LGPL). Download version 0.1.3.
IRMBase V1.0 is freely available here.
Contact
Amarendran R. Subramanian subraman@informatik.uni-tuebingen.de
Links
The alignment editor program STRAP by Christoph Gille supports DIALIGN-T as underlying protein alignment program.